Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 100%Moderate 0 · 0%High 0 · 0%

Higher dose vitamin K vs lower dose vitamin K

Presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.36 [0.24, 7.57]
1 study · 61 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.07 [0.41, 10.43]
1 study · 57 participants
Low

Higher dose vitamin K vs lower dose vitamin K

Presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.6]
1 study · 53 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.04 [0.07, 15.74]
1 study · 51 participants
Low