What do systematic reviews say?

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

It is very uncertain whether guidewire‐assisted cannulation changes perforation compared with contrast‐assisted cannulation (very low certainty).

• Guidewire‐assisted cannulation of the common bile duct for the prevention of post‐endoscopic retrograde… 2022 · Cochrane Headline outcomes only
  RR 0.93 [0.11, 8.23]
  8 studies · 2522 participants
  Very low