Findings

What do systematic reviews say?

5 questions · 11 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 9 · 81.8%Very low 2 · 18.2%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Amoxicillin + clavulanate + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

It is very uncertain whether amoxicillin + clavulanate + SRP changes percentage of bleeding on probing (BOP) compared with SRP (very low certainty).

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD 0.00 [-0.09, 0.09]
1 study · 21 participants
Very low
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -0.10 [-0.19, -0.01]
1 study · 21 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.10 [-0.19, -0.01]
1 study · 21 participants
GRADE not reported

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.60 [-14.03, 10.83]
1 study · 8 participants
GRADE not reported

Amoxicillin + metronidazole + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Amoxicillin + metronidazole + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

3 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -2.05 [-2.98, -1.11]
13 studies · 460 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -5.32 [-12.02, 1.37]
5 studies · 172 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
MD -8.06 [-14.26, -1.85]
2 studies · 389 participants
Very low

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 4.00 [-1.09, 9.09]
1 study · 46 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 5.40 [-0.12, 10.92]
1 study · 46 participants
GRADE not reported

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD 4.46 [-23.48, 32.40]
3 studies · 84 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD 20.85 [3.31, 38.39]
1 study · 22 participants
GRADE not reported