Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

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No studies found 1 · 50%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Topical clonidine (TC) vs placebo

Participant‐reported pain relief of 30% or greater · adults with painful diabetic neuropathy

It is very uncertain whether topical clonidine (TC) changes participant‐reported pain relief of 30% or greater during longest compared with placebo (very low certainty).

1 finding from 1 review

Topical clonidine for neuropathic pain in adults 2022 · Cochrane Headline outcomes only
RR 1.35 [1.03, 1.77]
2 studies · 344 participants
Very low

Topical clonidine (TC) vs active comparators

Participant‐reported pain relief of 30% or greater · adults with painful diabetic neuropathy

The review found no eligible studies for this question.

1 finding from 1 review

Topical clonidine for neuropathic pain in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found