Findings

What do systematic reviews say?

7 questions · 7 findings · 3 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

N‐acetylcysteine (1200 mg) vs placebo

Frequency of crisis (number of pain days) · sickle cell disease

N‐acetylcysteine (1200 mg) showed no clear difference in frequency of crisis (number of pain days) compared with placebo (low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
Rate ratio 0.99 [0.53, 1.84]
1 study · 96 participants
Low

N‐acetylcysteine (1200 mg) vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · sickle cell disease

N‐acetylcysteine (1200 mg) showed no clear difference in severity of pain (maximum pain intensity on pain days) compared with placebo (low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
MD 0.17
1 study · 96 participants
Low

Summary of findings: ECM vs ECT

Abdominal pain frequency or change in frequency · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: ECM changes frequency of bowel symptoms: abdominal pain (% of days affected) compared with ECT (very low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 41 participants
Very low

Summary of findings: ECM vs NECT plus cimetidine

Abdominal pain frequency or change in frequency · adults with cystic fibrosis

It is very uncertain whether summary of findings: ECM changes frequency in bowel symptoms: abdominal pain (% of days affected) compared with NECT plus cimetidine (very low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Summary of findings: ECM vs a different ECM

Abdominal pain frequency or change in frequency · adults and children with cystic fibrosis

Summary of findings: ECM (Creon®) showed no clear difference in frequency of bowel symptoms: proportion of days with abdominal pain compared with a different ECM (low certainty).

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 0
1 study · 83 participants
Low

Oral magnesium pidolate vs placebo or no intervention

Change in frequency of vaso‐occlusive painful crises (as measured by pain diary days with significant pain) · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Intravenous magnesium sulphate vs placebo

Change in frequency of vaso‐occlusive painful crises (as measured by pain diary days with significant pain) · people with sickle cell disease

1 finding from 1 review

Magnesium for treating sickle cell disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 104 participants
Moderate