Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%

Oral misoprostol vs vaginal misoprostol

Oxytocin augmentation · women in the third trimester for induction of labour.

Oral misoprostol may leads to higher oxytocin augmentationÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.28 [1.15, 1.44]
28 studies · 5416 participants
Low

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

Oxytocin augmentation · women in the third trimester for induction of labour with intact membranes

It is very uncertain whether oral misoprostol one‐ to two‐hourly changes oxytocin augmentation compared with oral misoprostol four‐ to six‐hourly (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1 [0.59, 1.68]
1 study · 64 participants
Very low

Oral misoprostol vs intravenous (IV) oxytocin

Oxytocin augmentation · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower oxytocin augmentation compared with intravenous oxytocin (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.12 [0.02, 0.85]
3 studies · 261 participants
Low

Oral misoprostol vs mechanical methods

Oxytocin augmentation · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower oxytocin augmentation compared with mechanical methods (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.79 [0.65, 0.95]
4 studies · 2708 participants
Low

Oral misoprostol vs placebo/no treatment

Oxytocin augmentation · women with ruptured membranes in the third trimester for induction of labour.

Oral misoprostol probably leads to lower oxytocin augmentation compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.46 [0.38, 0.55]
3 studies · 495 participants
Moderate

Oral misoprostol vs vaginal dinoprostone

Oxytocin augmentation · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes oxytocin augmentationÂ compared with vaginal dinoprostone (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.9 [0.75, 1.09]
12 studies · 9451 participants
Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Oxytocin augmentation · induction of labour.

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes oxytocin augmentation compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.04 [0.85, 1.27]
2 studies · 296 participants
Very low