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What do systematic reviews say?

3 questions · 6 findings · 2 reviews · Gynaecology and Fertility · asked by two or more reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%

Metformin combined with clomiphene citrate vs clomiphene

Ovulation rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate may leads to higher ovulation rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.65 [1.35, 2.03]
22 studies · 1601 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.57 [1.28, 1.92]
21 studies · 1624 participants
Moderate

Metformin vs clomiphene

Ovulation rate per woman fParticipants with BMI < 30 kg/m2 · women with polycystic ovary syndrome

Metformin showed no clear difference in ovulation rate per woman fParticipants with BMI < 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.8 [0.52, 1.25]
5 studies · 352 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.81 [0.51, 1.28]
4 studies · 312 participants
Low

Metformin vs clomiphene

Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.29 [0.2, 0.43]
2 studies · 500 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.29 [0.2, 0.43]
2 studies · 500 participants
Low