Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Radiosurgery alone vs WBRT and radiosurgery

Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases

Radiosurgery alone showed no clear difference in overall survivalNo. of participants: 403(3 RCTs) compared with WBRT and radiosurgery (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
HR 1 [0.8, 1.25]
Studies not reported
Moderate

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Overall survival · Patients with brain metastases

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in overall survival compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases 2017 · Cochrane Headline outcomes only
HR 0.82 [0.65, 1.02]
2 studies · 358 participants
Moderate

Intervention not reported

Overall Survival (median · Patients with brain metastases

The intervention showed no clear difference in overall Survival (median (low certainty).

1 finding from 1 review

Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases 2014 · Cochrane Headline outcomes only
HR 1.11 [0.83, 1.48]
5 studies · 663 participants
Low