Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Breast Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 1 · 33.3%High 1 · 33.3%

Platinum vs non‐platinum therapy

Overall survival (OS) · women with metastatic triple‐negative breast cancer (mTNBC)

Platinum showed no clear difference in overall survival (OS) compared with non‐platinum regimens (moderate certainty).

1 finding from 1 review

Platinum‐containing regimens for triple‐negative metastatic breast cancer 2020 · Cochrane Headline outcomes only
HR 0.85 [0.73, 1]
6 studies · 958 participants
Moderate

Intervention not reported

Overall survival ‐ trials of mTNBC participants · women with metastatic triple‐negative breast cancer (mTNBC)

The intervention showed no clear difference in overall survival ‐ trials of mTNBC participants (low certainty).

1 finding from 1 review

Platinum‐containing regimens for metastatic breast cancer 2017 · Cochrane Headline outcomes only
HR 0.75 [0.57, 1]
3 studies · 391 participants
Low

Intervention not reported

Overall survival ‐ trials of metastatic breast cancer participants unselected for TNBC · women with metastatic breast cancer unselected for triple‐negative breast cancer (TNBC)

The intervention showed no clear difference in overall survival ‐ trials of metastatic breast cancer participants… (high certainty).

1 finding from 1 review

Platinum‐containing regimens for metastatic breast cancer 2017 · Cochrane Headline outcomes only
HR 1.01 [0.92, 1.12]
16 studies · 2531 participants
High