Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 1 · 33.3%High 1 · 33.3%

Hypofractionated radiotherapy vs radiotherapy

Overall survival · children and young adults with diffuse brainstem glioma

Hypofractionated radiotherapy showed no clear difference in overall survival compared with conventional radiotherapy (moderate certainty).

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
HR 1.03 [0.53, 2.01]
1 study · 71 participants
Moderate

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Overall survival · high‐grade glioma

It is very uncertain whether hypofractionated radiotherapy changes overall survival compared with daily conventionally fractionated radiotherapy (very low certainty).

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
HR 0.95 [0.78, 1.17]
5 studies · 943 participants
Very low

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Overall survival for subgroup age 60 years and older glioblastoma · high‐grade glioma

Hypofractionated radiotherapy showed no clear difference in overall survival for subgroup aged ≥ 60 years glioblastoma compared with daily conventionally fractionated radiotherapy (high certainty).

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
HR 1.16 [0.92, 1.46]
2 studies · 293 participants
High