What do systematic reviews say?

Fast‐acting nicotine replacement therapy vs nicotine patch

• Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1252 participants
  Very low

Preloading nicotine replacement therapy (NRT) vs standard‐use NRT

Preloading nicotine replacement therapy (NRT) showed no clear difference in overall serious adverse events compared with standard‐use NRT (low certainty).

• Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
  RR 1.11 [0.59, 2.09]
  4 studies · 3908 participants
  Low

Longer vs shorter duration of nicotine patch therapy

• Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1173 participants
  Very low

Combination vs nicotine replacement therapy monotherapy

Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).

• Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
  RR 4.44 [0.76, 25.85]
  5 studies · 2888 participants
  Low

Intervention not reported

• Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported