What do systematic reviews say?

Combination vs nicotine replacement therapy monotherapy

Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).

• Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation 2023 · Cochrane Headline outcomes only
  RR 4.44 [0.76, 25.85]
  5 studies · 2888 participants
  Low