Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Common Mental Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 2 · 66.7%High 0 · 0%

Overall rate of adverse events · adults with a history of SAD who do not fulfil criteria for major depressive disorder

Bupropion XL showed no clear difference in overall rate of adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Second‐generation antidepressants for preventing seasonal affective disorder in adults 2019 · Cochrane Headline outcomes only
RR 1.02 [0.97, 1.08]
3 studies · 1048 participants
Moderate

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

Amitriptyline probably leads to higher overall tolerability Drop‐out due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Amitriptyline versus placebo for major depressive disorder 2012 · Cochrane Headline outcomes only
OR 4.15 [2.71, 6.35]
19 studies · 2174 participants
Moderate

Overall adverse events 5 weeks · adults with seasonal affective disorder

It is very uncertain whether fluoxetine changes overall adverse events 5 weeks compared with placebo (very low certainty).

1 finding from 1 review

Second‐generation antidepressants for treatment of seasonal affective disorder 2021 · Cochrane Headline outcomes only
RR 1.07 [0.95, 1.21]
1 study · 68 participants
Very low