What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Oral medicine and oral cancer

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No studies found 0 · 0%GRADE not reported 4 · 80%Very low 0 · 0%Low 1 · 20%Moderate 0 · 0%High 0 · 0%

Periodontitis vs Individuals without periodontal disease (by LOA)

Malignant transformation (oral cancer development) · Adults in case-control studies of oral cancer; people assessed for periodontitis

Periodontitis is associated with roughly a threefold higher odds of oral cancer (pooled OR 2.94, 95% CI 2.13-4.07; low certainty of evidence), though heterogeneity is moderate (I2=52.4%).

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · Overall (random-effects pooled estimate)
OR 2.94 [2.13, 4.07]
8 studies · 6927 participants
Low

Higher number of lost teeth (per one additional lost tooth) vs One fewer missing tooth

Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)

The number of missing teeth (per tooth) was not significantly associated with oral cancer (OR 0.96, 95% CI 0.92-1.01); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · Missing teeth (per tooth)
OR 0.96 [0.92, 1.01]
2 studies
GRADE not reported

More than 15 missing teeth vs 15 or fewer missing teeth

Oral cancer risk · People with and without more than 15 missing teeth

More than 15 missing teeth was associated with higher odds of oral cancer.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Missing teeth >15
OR 1.91 [1.01, 3.62]
5 studies
GRADE not reported

Missing teeth / tooth loss vs Fewer or no missing teeth

Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)

Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · Overall (all missing-teeth measures pooled)
OR 1.20 [0.97, 1.48]
6 studies
GRADE not reported

Intervention not reported

Oral cancer (OC)

The intervention led to higher oral cancer (OC); GRADE not reported.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Sensitivity analysis: excluding Moraes et al. [34]
OR 2.63 [1.92, 3.62]
7 studies
GRADE not reported