Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 50%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

Progesterone vs no treatment or placebo (route of progesterone administration)

Live birth or ongoing pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in live birth/ongoing pregnancy rate compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.1 [0.81, 1.48]
7 studies · 1792 participants
Low

Oral progesterone vs vaginal progesterone

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether oral progesterone changes ongoing pregnancy rate compared with vaginal progesterone (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.25 [0.7, 2.22]
1 study · 150 participants
Very low

Progesterone vs placebo/no treatment

Ongoing pregnancy · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in ongoing pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.73 [0.37, 1.42]
1 study · 253 participants
Low

Progesterone vs placebo/no treatment

Live birth or ongoing pregnancy · women with oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in live birth rate/ongoing pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.97 [0.58, 1.64]
2 studies · 485 participants
Low

300 mg vaginal progesterone vs vaginal progesterone

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether 300 mg vaginal progesterone changes ongoing pregnancy rate compared with 600 mg vaginal progesterone (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.58 [0.81, 3.09]
1 study · 200 participants
Very low

Progesterone vs placebo/no treatment

Live birth or ongoing pregnancy · women with gonadotropin stimulation

Progesterone showed no clear difference in live birth rate/ongoing pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.24 [0.8, 1.92]
4 studies · 1054 participants
Low

Intramuscular (IM) progesterone vs vaginal progesterone

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether intramuscular (IM) progesterone changes ongoing pregnancy rate compared with vaginal progesterone (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.59 [0.34, 1.02]
1 study · 225 participants
Very low

Aqueous subcutaneous (Sc) progesterone vs vaginal progesterone

Ongoing pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether aqueous subcutaneous (Sc) progesterone changes ongoing pregnancy rate compared with vaginal progesterone gel (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.05 [0.54, 2.05]
1 study · 246 participants
Very low