What do systematic reviews say?

Summary of findings: punctal plugs vs pilocarpine

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Summary of findings: punctal plugs vs no punctal plugs

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 61 participants
  Low

Summary of findings: punctal plugs vs artificial tears

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Summary of findings: punctal plugs in the upper vs lower puncta

The review found no eligible studies for this question.

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: acrylic vs silicone punctal plugs

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Summary of findings: intracanalicular vs silicone punctal plugs

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Summary of findings table ‐ Collagen vs silicone punctal plugs

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Summary of findings: punctal plugs vs cyclosporine A

• Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone

• Topical cyclosporine A therapy for dry eye syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 291 participants
  Low

Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy

The review found no eligible studies for this question.

• Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral long‐chain omega‐3 PUFAs vs oral omega‐6 PUFAs

Oral long‐chain omega‐3 PUFAs showed no clear difference in change in ocular surface staining at 1‐month compared with oral omega‐6 PUFAs (low certainty).

• Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 709 participants
  Low

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

• Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 3 participants
  Moderate

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) showed no clear difference in change in ocular surface staining at 1‐month (with actual compared with placebo or no treatment (low certainty).

• Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
  MD 0.1
  4 studies · 681 participants
  Low