Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 6 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 50%Low 4 · 33.3%Moderate 1 · 8.3%High 1 · 8.3%

LOD vs medical interventions

Harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of participants: 332 (2 RCTs) Harms: OHSS rates at 6 months ‐ LOD vs gonadotrophins N of participants: 33 (1 RCT) · Women with symptoms of PCOS

LOD probably leads to lower harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of… compared with medical interventions (moderate certainty).

1 finding from 1 review

Recombinant follicle stimulating hormone vs urinary‐derived gonadotrophins

OHSS · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether recombinant follicle stimulating hormone changes incidence of OHSS per woman compared with urinary‐derived gonadotrophins (very low certainty).

1 finding from 1 review

rFSH vs urinary‐derived gonadotrophins

OHSS by urinary gonadotrophin · patients with ovarian stimulation in assisted reproductive technology cycles

rFSH showed no clear difference in OHSS by urinary gonadotrophin compared with urinary gonadotrophins: primary analyses (high certainty).

1 finding from 1 review

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only vs monitoring with TVUS plus serum estradiol

OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in OHSS rate (mild, moderate or severe) per woman compared with monitoring with TVUS plus serum estradiol (low certainty).

1 finding from 1 review

Human menopausal gonadotrophin or highly purified human menopausal gonadotrophin vs urinary follicle stimulating hormone

OHSS · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether human menopausal gonadotrophin or highly purified human menopausal… changes incidence of OHSS per woman compared with urinary follicle stimulating hormone (very low certainty).

1 finding from 1 review