Gonadotrophins vs continued clomiphene citrate
- Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 661 participantsLow
Gonadotrophins with anti‐oestrogens showed no clear difference in OHSS rate per couple compared with gonadotropins alone (low certainty).
LOD probably leads to lower harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of… compared with medical interventions (moderate certainty).
Coasting may leads to lower OHSS compared with no coasting (low certainty).
It is very uncertain whether coasting changes OHSS compared with follicle stimulating hormone administration at time of hCG (very low certainty).
It is very uncertain whether coasting changes OHSS compared with cabergoline (very low certainty).
It is very uncertain whether coasting changes OHSS compared with early unilateral follicular aspiration (very low certainty).
It is very uncertain whether recombinant follicle stimulating hormone changes incidence of OHSS per woman compared with urinary‐derived gonadotrophins (very low certainty).
rFSH showed no clear difference in OHSS by urinary gonadotrophin compared with urinary gonadotrophins: primary analyses (high certainty).
Monitoring ovarian stimulation by transvaginal ultrasound (TVUS) only showed no clear difference in OHSS rate (mild, moderate or severe) per woman compared with monitoring with TVUS plus serum estradiol (low certainty).
It is very uncertain whether human menopausal gonadotrophin or highly purified human menopausal… changes incidence of OHSS per woman compared with urinary follicle stimulating hormone (very low certainty).