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What do systematic reviews say?

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Evidence found and GRADE certainty

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clonidine vs midazolam

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine · patients with postoperative pain

Clonidine may leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with midazolam (low certainty).

1 finding from 1 review

Clonidine vs placebo or no treatment

Number requiring additional analgesia at any time postoperatively ‐ high dose clonidine, studies with lower risk of bias · patients with postoperative pain

Clonidine probably leads to lower number requiring additional analgesia at any time postoperatively ‐… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review