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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Musculoskeletal

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%

Tramadol vs paracetamol

Withdrawals due to adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants who withdrew due to adverse events compared with acetaminophen (very low certainty).

1 finding from 1 review

Tramadol vs NSAIDs

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with NSAIDs (low certainty).

1 finding from 1 review

Tramadol vs other opioids

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with other opioids (low certainty).

1 finding from 1 review

Tramadol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone probably leads to higher number of participants who withdrew due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review