Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Musculoskeletal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 2.78 [1.5, 5.16]
2 studies · 614 participants
Low

Tramadol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone probably leads to higher number of participants who withdrew due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 2.64 [2.17, 3.2]
9 studies · 4533 participants
Moderate

Bisphosphonates vs placebo

Withdrawals due to adverse events · Paget's disease of bone

Bisphosphonates showed no clear difference in number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
RR 1.01 [0.41, 2.52]
6 studies · 517 participants
Low