What do systematic reviews say?

Macrolides vs tetracycline

Macrolide showed no clear difference in number of participants experiencing one or more exacerbations… compared with tetracycline (low certainty).

• Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
  OR 0.44 [0.14, 1.38]
  1 study · 50 participants
  Low