Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Musculoskeletal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Celecoxib for osteoarthritis 2017 · Cochrane Headline outcomes only
Peto OR 0.95 [0.66, 1.36]
22 studies · 10926 participants
Very low

Number of participants experiencing any serious adverse events · patients with osteoarthritis

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Low

Number of participants experiencing any serious adverse events · Patients with osteoarthritis of the knee or hip

Tramadol alone may leads to higher number of participants experiencing any serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 1.78 [1.11, 2.84]
7 studies · 3612 participants
Low