What do systematic reviews say?

Metoprolol vs placebo

Metoprolol showed no clear difference in nonfatal cardiovascular event, 30 days5 compared with placebo (low certainty).

• Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with… 2017 · Cochrane Headline outcomes only
  OR 1.44 [0.58, 3.57]
  1 study · 227 participants
  Low