Findings

What do systematic reviews say?

7 questions · 7 findings · 3 reviews · Headline outcomes only

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No studies found 4 · 57.1%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Diet vs physical activity or standard treatment

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse event outcomes for dietary combined with physical activity interventions vs usual care

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

1 finding from 1 review

Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications… 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 102 participants
Low

Summary of findings: pioglitazone monotherapy vs intensive behaviour‐changing intervention

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: pioglitazone monotherapy vs no intervention

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Physical activity vs usual care

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

1 finding from 1 review

Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications… 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 123 participants
Very low

Summary of findings: pioglitazone monotherapy vs placebo

Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes non‐fatal myocardial infarction/stroke (N) compared with placebo (very low certainty).

1 finding from 1 review

Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
RR 1.97 [0.18, 21.65]
3 studies · 789 participants
Very low