Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 2 · 50%GRADE not reported 0 · 0%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 1 · 25%

Summary of findings: Inhaled antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics changes need for additional IV or oral antibiotics compared with IV antibiotics (very low certainty).

1 finding from 1 review

Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis 2022 · Cochrane Headline outcomes only
RR 6.11 [0.33, 111.71]
1 study · 18 participants
Very low

Summary of findings: Inhaled antibiotics plus IV antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral azithromycin vs placebo

Need for additional antibiotics: participants needing extra IV antibiotics · adults and children with cystic fibrosis

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 527 participants
High

Summary of findings ‐ nebulised azithromycin vs azithromycin

Need for additional antibiotic therapy · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found