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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 3 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 4 · 57.1%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 0 · 0%Moderate 1 · 14.3%High 1 · 14.3%

Summary of findings: Inhaled antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics changes need for additional IV or oral antibiotics compared with IV antibiotics (very low certainty).

1 finding from 1 review

Summary of findings: aztreonam lysine for inhalation vs tobramycin

Need for antibiotics see pulmonary exacerbations · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: aztreonam lysine for inhalation probably leads to lower pulmonary exacerbations: need for additional antibiotics compared with tobramycin (moderate certainty).

1 finding from 1 review