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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews · Headline outcomes only

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No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Late paracetamol vs placebo or no intervention

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Late paracetamol showed no clear difference in necrotizing enterocolitis during initial hospital stay (by… compared with placebo/no intervention (low certainty).

1 finding from 1 review

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in necrotizing enterocolitis during initial hospital stay (radiological… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

1 finding from 1 review

Paracetamol vs ibuprofen

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Paracetamol showed no clear difference in necrotizing enterocolitisduring initial hospital stay (by… compared with ibuprofen (moderate certainty).

1 finding from 1 review