Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 1 · 50%Moderate 0 · 0%High 0 · 0%

Metformin vs placebo co‐treatment

Multiple pregnancy rate · subfertile women with polycystic ovary syndrome

Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 0.55 [0.15, 1.95]
4 studies · 232 participants
Low

Glucocorticoid supplementation vs placebo

Multiple pregnancy rate · Women undergoing IVF/ICSI cycles

It is very uncertain whether glucocorticoid supplementation changes multiple pregnancy rate per woman/couple compared with placebo (very low certainty).

1 finding from 1 review

Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI 2017 · Cochrane Headline outcomes only
OR 3.32 [0.12, 91.6]
1 study · 20 participants
Very low