Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 0 · 0%High 1 · 33.3%

Letrozole vs laparoscopic ovarian drilling

Multiple pregnancy rate · infertile women with polycystic ovary syndrome

It is very uncertain whether letrozole changes multiple pregnancy rate compared with laparoscopic ovarian drilling (very low certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 3 [0.12, 74.9]
1 study · 141 participants
Very low

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Multiple pregnancy rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in multiple pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 0.74 [0.42, 1.32]
14 studies · 2247 participants
High

Progesterone vs placebo/no treatment

Multiple pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in multiple pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.44 [0.24, 8.49]
1 study · 290 participants
Low