Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Single vs multiple embryo transfer

Multiple pregnancy · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Single probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 0.16 [0.12, 0.22]
13 studies · 1952 participants
Moderate

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Multiple pregnancy · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) probably leads to lower multiple pregnancy compared with multiple embryo transfer (moderate certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 0.13 [0.08, 0.21]
4 studies · 985 participants
Moderate

Double intrauterine insemination (IUI) vs single IUI

Multiple pregnancy rate · stimulated cycles for subfertile couples

Double intrauterine insemination (IUI) showed no clear difference in multiple pregnancy ratea compared with single IUI (low certainty).

1 finding from 1 review

Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples 2021 · Cochrane Headline outcomes only
OR 2.04 [0.91, 4.56]
5 studies · 2203 participants
Low