What do systematic reviews say?

Bile acids vs no intervention

It is very uncertain whether bile acids changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for non‐alcohol related fatty liver disease (NAFLD) 2017 · Cochrane Headline outcomes only
  OR 5.11 [0.24, 107.34]
  4 studies · 659 participants
  Very low

Thiazolidinediones vs no intervention

• Pharmacological interventions for non‐alcohol related fatty liver disease (NAFLD) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Very low

Glucocorticosteroids vs no intervention

It is very uncertain whether glucocorticosteroids changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 0.85 [0.67, 1.08]
  12 studies · 1147 participants
  Very low

Colchicine vs no intervention

It is very uncertain whether colchicine changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 1.31 [0.47, 3.64]
  2 studies · 139 participants
  Very low

Insulin plus glucagon vs no intervention

It is very uncertain whether insulin plus glucagon changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 1.14 [0.69, 1.9]
  5 studies · 265 participants
  Very low

Propylthiouracil vs no intervention

It is very uncertain whether propylthiouracil changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 1.16 [0.5, 2.72]
  2 studies · 108 participants
  Very low

Glucocorticosteroids vs no intervention

It is very uncertain whether glucocorticosteroids changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 0.88 [0.63, 1.21]
  2 studies · 607 participants
  Very low

Pentoxifylline vs no intervention

It is very uncertain whether pentoxifylline changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 0.8 [0.59, 1.07]
  4 studies · 726 participants
  Very low

Anabolic steroids vs no intervention

It is very uncertain whether anabolic steroids changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 1.29 [0.7, 2.39]
  2 studies · 248 participants
  Very low

Antioxidants vs no intervention

It is very uncertain whether antioxidants changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 1.96 [0.99, 3.89]
  2 studies · 255 participants
  Very low

Colchicine vs no intervention

It is very uncertain whether colchicine changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 1.11 [0.8, 1.53]
  2 studies · 604 participants
  Very low

Propylthiouracil vs no intervention

Propylthiouracil may leads to lower mortality at maximal compared with no intervention (low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 0.45 [0.26, 0.78]
  2 studies · 423 participants
  Low

Pentoxifylline vs no intervention

It is very uncertain whether pentoxifylline changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for alcoholic liver disease (alcohol‐related liver disease) 2017 · Cochrane Headline outcomes only
  OR 0.77 [0.58, 1.02]
  6 studies · 881 participants
  Very low

Ursodeoxycholic acid vs no intervention

It is very uncertain whether ursodeoxycholic acid (UDCA) changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 0.99 [0.6, 1.64]
  6 studies · 734 participants
  Very low

Ciclosporin vs no intervention

It is very uncertain whether ciclosporin changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 0.88 [0.51, 1.5]
  3 studies · 390 participants
  Very low

D‐Penicillamine vs no intervention

It is very uncertain whether D‐Penicillamine changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 0.9 [0.57, 1.44]
  5 studies · 423 participants
  Very low

Colchicine plus ursodeoxycholic acid (UDCA) vs UDCA

It is very uncertain whether colchicine plus ursodeoxycholic acid (UDCA) changes mortality at maximal compared with UDCA (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 1.84 [0.38, 8.91]
  2 studies · 158 participants
  Very low

Methotrexate plus ursodeoxycholic acid (UDCA) vs UDCA

It is very uncertain whether methotrexate plus ursodeoxycholic acid (UDCA) changes mortality at maximal compared with UDCA (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 1.17 [0.55, 2.51]
  2 studies · 290 participants
  Very low

Azathioprine vs no intervention

It is very uncertain whether azathioprine changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 0.56 [0.32, 0.98]
  2 studies · 224 participants
  Very low

Colchicine vs no intervention

It is very uncertain whether colchicine changes mortality at maximal compared with no intervention (very low certainty).

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  OR 0.77 [0.32, 1.85]
  2 studies · 122 participants
  Very low