Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Methylprednisolone plus azathioprine vs methylprednisolone plus dapsone

Mortality at 1 year · bullous pemphigoid

It is very uncertain whether methylprednisolone plus azathioprine changes mortality at 1 year compared with methylprednisolone plus dapsone (very low certainty).

1 finding from 1 review

Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
RR 0.33 [0.04, 3.01]
1 study · 54 participants
Very low

Intervention not reported

All‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs incretin‐based control [d. 52 weeks to... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in all‐cause mortality a. Intervention vs metformin [a. 24 weeks to 4… (low certainty).

1 finding from 1 review

Sulphonylurea monotherapy for patients with type 2 diabetes mellitus 2013 · Cochrane Headline outcomes only
RR 0.98 [0.61, 1.58]
6 studies · 3528 participants
Low

Intervention not reported

Cardiovascular mortality a. Intervention vs metformin [a. 24 weeks to 4 years] b. Intervention vs thiazolidinediones [b. 24 weeks to 4 years] c. Intervention vs insulin [c. 9 months to 10 years] d. Intervention vs meglitinide [d. 12 months to 17 m... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in cardiovascular mortality a. Intervention vs metformin [a. 24 weeks… (low certainty).

1 finding from 1 review

Sulphonylurea monotherapy for patients with type 2 diabetes mellitus 2013 · Cochrane Headline outcomes only
RR 1.47 [0.54, 4.01]
6 studies · 3528 participants
Low

DFP and DFO vs DFP and DFX

Death by end of trial

It is very uncertain whether summary of findings: Comparison 7 ‐ deferiprone (DFP) plus… changes all‐cause mortality ‐ at 1 year ‐ trial end compared with DFP plus deferasirox (DFX) (very low certainty).

1 finding from 1 review

Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
RD 0
1 study · 96 participants
Very low

Clobetasol propionate cream vs prednisone

Mortality at 1 year · bullous pemphigoid

Clobetasol propionate cream showed no clear difference in mortality at 1 year compared with oral prednisone (low certainty).

1 finding from 1 review

Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
RR 0.73 [0.53, 1.01]
1 study · 341 participants
Low

Doxycycline vs prednisolone

Treatment‐related mortality at 1 year (mITT) · bullous pemphigoid

Doxycycline probably leads to lower treatment‐related mortality at 1 year (mITT) compared with prednisolone (moderate certainty).

1 finding from 1 review

Interventions for bullous pemphigoid 2023 · Cochrane Headline outcomes only
RR 0.25 [0.07, 0.89]
1 study · 234 participants
Moderate