Sildenafil vs placebo
All‐cause mortality · pulmonary hypertension in neonates
Sildenafil may leads to lower all‐cause mortality compared with placebo (low certainty).
1 finding from 1 review
- RR 0.2 [0.07, 0.56]3 studies · 77 participantsLow
Findings
What do systematic reviews say?
6 questions · 6 findings · 4 reviews · Neonatal
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%
Sildenafil vs active control
All‐cause mortality · pulmonary hypertension in neonates
It is very uncertain whether sildenafil changes all‐cause mortality compared with active control (very low certainty).
1 finding from 1 review
- RR 0.55 [0.05, 5.75]1 study · 65 participantsVery low
Sildenafil plus iNO vs placebo plus iNO
All‐cause mortality · pulmonary hypertension in neonates
Sildenafil plus iNO showed no clear difference in all‐cause mortality compared with placebo plus iNO (low certainty).
1 finding from 1 review
- RR 1.27 [0.26, 6.28]1 study · 24 participantsLow
Intervention not reported
Mortality during hospital stay · neonates requiring intubation and ventilation
The intervention showed no clear difference in mortality during hospital stay (moderate certainty).
1 finding from 1 review
- Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes onlyRR 0.79 [0.4, 1.56]3 studies · 122 participantsModerate
Summary of findings table ‐ Silicone earplugs vs no earplugs
All‐cause mortality during hospital stay · preterm or very low birth weight infants
It is very uncertain whether summary of findings table ‐ Silicone earplugs changes all‐cause mortality during hospital stay compared with no earplugs (very low certainty).
1 finding from 1 review
- Noise or sound management in the neonatal intensive care unit for preterm or very low birth weight infants 2024 · Cochrane Headline outcomes onlyRR 2.07 [0.64, 6.7]1 study · 34 participantsVery low
Supine midline head position vs any other supine head position
All‐cause mortality during hospital stay · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants
It is very uncertain whether supine midline head position changes mortality during initial hospitalisation compared with any other supine head position (very low certainty).
1 finding from 1 review
- Head midline position for preventing the occurrence or extension of germinal matrix‐intraventricular haemorrhage in… 2020 · Cochrane Headline outcomes onlyRR 0.5 [0.28, 0.9]3 studies · 290 participantsVery low