Findings

What do systematic reviews say?

4 questions · 4 findings · 4 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 1 · 25%Moderate 0 · 0%High 1 · 25%

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Surgically‐related postoperative mortality (28 days to 6 months of surgery4) · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) leads to lower surgically‐related postoperative mortality (28 days to 6 months of… compared with surgery followed by chemotherapy (PDS) (high certainty).

1 finding from 1 review

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced… 2021 · Cochrane Headline outcomes only
RR 0.16 [0.06, 0.46]
5 studies · 1623 participants
High

Ultra‐radical (extensive) surgery vs surgery

Perioperative mortality · women with stage IIIc or IV ovarian cancer

It is very uncertain whether ultra‐radical (extensive) surgery changes adverse event: perioperative mortality compared with standard surgery (very low certainty).

1 finding from 1 review

Ultra‐radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 397 participants
Very low

Enhanced recovery protocol vs traditional care

Mortality (within 30 days of discharge) · women with gynaecological cancers

It is very uncertain whether enhanced recovery after surgery programme changes mortality (within 30 days of discharge) compared with traditional care (very low certainty).

1 finding from 1 review

Perioperative enhanced recovery programmes for women with gynaecological cancers 2022 · Cochrane Headline outcomes only
RR 0.98 [0.14, 6.68]
1 study · 99 participants
Very low

Primary Groin Radiotherapy vs Primary Groin Surgery

Disease specific mortality · patients with Early Vulvar Cancer

Primary Groin Radiotherapy showed no clear difference in disease specific mortality compared with primary Groin Surgery (low certainty).

1 finding from 1 review

Primary groin irradiation versus primary groin surgery for early vulvar cancer 2011 · Cochrane Headline outcomes only
RR 3.7 [0.87, 15.8]
1 study · 52 participants
Low