Findings

What do systematic reviews say?

6 questions · 8 findings · 3 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 7 · 87.5%Moderate 0 · 0%High 0 · 0%

Metformin vs placebo or no treatment

Miscarriage · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 0.86 [0.56, 1.32]
8 studies · 821 participants
Low
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.08 [0.5, 2.35]
4 studies · 748 participants
Low

Metformin vs clomiphene

Miscarriage · women with polycystic ovary syndrome

It is very uncertain whether metformin changes miscarriage rate per woman compared with clomiphene citrate (very low certainty).

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.92 [0.5, 1.67]
5 studies · 741 participants
Very low

Metformin vs placebo or no treatment

Miscarriage · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.08 [0.5, 2.35]
4 studies · 748 participants
Low

Metformin vs clomiphene

Miscarriage rate per woman aParticipants with BMI < 30 kg/2 · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI < 30 kg/2 compared with clomiphene citrate (low certainty).

1 finding from 1 review

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.51 [0.62, 3.71]
4 studies · 281 participants
Low

Metformin vs clomiphene

Miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

1 finding from 1 review

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.61 [0.27, 1.38]
2 studies · 500 participants
Low

Metformin combined with clomiphene citrate vs clomiphene

Miscarriage · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in miscarriage rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.35 [0.91, 2]
10 studies · 1206 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1.03, 2.46]
9 studies · 1096 participants
Low