Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 75%Moderate 0 · 0%High 1 · 25%

Letrozole vs laparoscopic ovarian drilling

Miscarriage · infertile women with polycystic ovary syndrome

Letrozole showed no clear difference in miscarriage rate per pregnancy compared with laparoscopic ovarian drilling (low certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 0.65 [0.22, 1.92]
3 studies · 122 participants
Low

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Miscarriage · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in miscarriage rate per pregnancy compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 0.94 [0.66, 1.32]
15 studies · 736 participants
High

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.67 [0.3, 1.5]
2 studies · 123 participants
Low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.53 [0.25, 1.14]
2 studies · 119 participants
Low