Findings

What do systematic reviews say?

5 questions · 5 findings · 4 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 1 · 20%High 1 · 20%

Minor bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

DOAC showed no clear difference in bleeding ‐ minor Treatment duration 28 ‐ 42 days compared with placebo (moderate certainty).

1 finding from 1 review

Minor bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

DOAC showed no clear difference in bleeding ‐ minor Treatment duration 28 ‐ 42 days compared with heparin (high certainty).

1 finding from 1 review

Minor bleeding · atrial fibrillation patients with CKD

Direct oral anticoagulants (DOAC) showed no clear difference in minor bleeding compared with warfarin (low certainty).

1 finding from 1 review

Minor bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in minor bleeding compared with no prophylaxis (low certainty).

1 finding from 1 review

Minor bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes minor bleeding compared with direct oral anticoagulants (DOAC) (very low certainty).

1 finding from 1 review