Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Heart

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 66.7%Moderate 1 · 33.3%High 0 · 0%

Major bleeding · patients with heart failure with sinus rhythm

Warfarin may leads to higher major bleeding eventsc compared with placebo or no treatment (low certainty).

1 finding from 1 review

Anticoagulation versus placebo for heart failure in sinus rhythm 2021 · Cochrane Headline outcomes only
OR 5.98 [1.71, 20.93]
2 studies · 324 participants
Low

Major bleeding · patients with heart failure with sinus rhythm

Summary of findings: warfarin probably leads to higher major bleeding events compared with aspirin (moderate certainty).

1 finding from 1 review

Antiplatelet versus anticoagulation treatment for patients with heart failure in sinus rhythm 2016 · Cochrane Headline outcomes only
RR 2 [1.44, 2.78]
4 studies · 3663 participants
Moderate

Major bleeding · patients with heart failure with sinus rhythm

Summary of findings: warfarin may leads to higher major bleeding events compared with clopidogrel (low certainty).

1 finding from 1 review

Antiplatelet versus anticoagulation treatment for patients with heart failure in sinus rhythm 2016 · Cochrane Headline outcomes only
RR 2.47 [1.24, 4.91]
1 study · 1064 participants
Low