What do systematic reviews say?

DOAC vs variable dose warfarin

Direct oral anticoagulants (DOAC) showed no clear difference in major bleeding compared with warfarin (low certainty).

• Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation… 2017 · Cochrane Headline outcomes only
  RR 0.79 [0.59, 1.04]
  5 studies · 12521 participants
  Low