Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 80%Low 1 · 20%Moderate 0 · 0%High 0 · 0%

Maintenance of remission · Patients with quiescent ulcerative colitis

Methotrexate showed no clear difference in maintenance of remission compared with placebo (low certainty).

1 finding from 1 review

Methotrexate for maintenance of remission in ulcerative colitis 2015 · Cochrane Headline outcomes only
RR 0.64 [0.28, 1.45]
1 study · 32 participants
Low

Maintenance of remission · Patients with quiescent ulcerative colitis

It is very uncertain whether methotrexate changes maintenance of remission compared with 5‐ASA (very low certainty).

1 finding from 1 review

Methotrexate for maintenance of remission in ulcerative colitis 2015 · Cochrane Headline outcomes only
RR 1.12 [0.06, 20.71]
1 study · 9 participants
Very low

Maintenance of remission · Maintenance of remission in ulcerative colitis

It is very uncertain whether methotrexate changes maintenance of Remission compared with 6‐MP (very low certainty).

1 finding from 1 review

Methotrexate for maintenance of remission in ulcerative colitis 2015 · Cochrane Headline outcomes only
RR 0.22 [0.03, 1.45]
1 study · 18 participants
Very low

Maintenance of remission · Maintenance of remission in ulcerative colitis

It is very uncertain whether methotrexate + sulfasalazine changes maintenance of Remission compared with sulfasalazine (very low certainty).

1 finding from 1 review

Methotrexate for maintenance of remission in ulcerative colitis 2015 · Cochrane Headline outcomes only
RR 1.32 [0.94, 1.86]
1 study · 26 participants
Very low

Maintenance of remission · maintenance of remission in Crohn's disease

It is very uncertain whether 6‐Mercaptopurine changes maintenance of remission compared with methotrexate (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine for maintenance of remission in Crohn's disease 2015 · Cochrane Headline outcomes only
RR 0.94 [0.47, 1.85]
1 study · 31 participants
Very low