What do systematic reviews say?

Reduction and pharmacotherapy vs reduction alone

Reduction and pharmacotherapy may leads to higher main analysis (all pharmacotherapy): smoking cessation (≥ 6 month compared with reduction alone (low certainty).

• Smoking reduction interventions for smoking cessation 2019 · Cochrane Headline outcomes only
  RR 1.68 [1.09, 2.58]
  11 studies · 8636 participants
  Low