What do systematic reviews say?

Intervention not reported

The review found no eligible studies for this question.

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention probably leads to lower moderate to severe exacerbations ‐ MD TRIPLE vs MD‐ICS/LABA№ of… (moderate certainty).

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  RR 0.86 [0.75, 0.99]
  3 studies · 3184 participants
  Moderate

Intervention not reported

The intervention leads to lower moderate to severe exacerbations ‐ HD TRIPLE vs MD‐ICS/LABA№ of… (high certainty).

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  RR 0.78 [0.66, 0.92]
  2 studies · 2037 participants
  High

Intervention not reported

The intervention showed no clear difference in moderate to severe exacerbations ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of… (high certainty).

• Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and varying… 2022 · Cochrane Headline outcomes only
  RR 0.93 [0.82, 1.05]
  6 studies · 5452 participants
  High

Intervention not reported

• Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 7569 participants
  Moderate