Findings

What do systematic reviews say?

5 questions · 5 findings · 3 reviews

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 1 · 20%High 1 · 20%

Letrozole vs laparoscopic ovarian drilling

Live birth rate · infertile women with polycystic ovary syndrome

It is very uncertain whether letrozole changes live birth rate compared with laparoscopic ovarian drilling (very low certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 2.07 [0.99, 4.32]
1 study · 141 participants
Very low

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Live birth rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts leads to higher live birth rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 1.72 [1.4, 2.11]
11 studies · 2060 participants
High

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 4.48 [2, 10.01]
1 study · 201 participants
Moderate

Progesterone vs placebo/no treatment

Live birth rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

The review found no eligible studies for this question.

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Progesterone vs placebo/no treatment

Live birth or ongoing pregnancy · women with oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in live birth rate/ongoing pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.97 [0.58, 1.64]
2 studies · 485 participants
Low