Findings

What do systematic reviews say?

44 questions · 47 findings · 28 reviews

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No studies found 6 · 12.8%GRADE not reported 1 · 2.1%Very low 11 · 23.4%Low 24 · 51.1%Moderate 5 · 10.6%High 0 · 0%

Metformin vs placebo or no treatment

Live birth rate per woman ‐ long protocol GnRH‐agonist · women with polycystic ovary syndrome

Metformin showed no clear difference in live birth rate per woman ‐ long protocol GnRH‐agonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.3 [0.94, 1.79]
6 studies · 651 participants
Low

Metformin vs placebo or no treatment

Live birth rate per woman ‐ short protocol GnRH‐antagonist · women with polycystic ovary syndrome

Metformin may leads to lower live birth rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 0.48 [0.29, 0.79]
1 study · 153 participants
Low

Endometrial injury vs control

Live birth rate per woman · women undergoing assisted reproduction

Endometrial injury showed no clear difference in live birth per woman randomised (studies at low risk of selection… compared with control (moderate certainty).

3 findings from 1 review

Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
OR 1.12 [0.98, 1.28]
8 studies · 4402 participants
Moderate
Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
OR 1.13 [0.63, 2.03]
1 study · 229 participants
Low
Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
no estimate extracted
29 studies · 7792 participants
Very low

Higher vs lower degree of injury

Live birth rate per woman · women undergoing assisted reproduction

It is very uncertain whether higher changes live birth per woman randomised: sensitivity analysis (including all… compared with lower degree of injury (very low certainty).

1 finding from 1 review

Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
OR 1.28 [0.31, 5.37]
1 study · 129 participants
Very low