Findings

What do systematic reviews say?

5 questions · 6 findings · 2 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Cognitive behavioural therapy + intensive case management vs usual care

Lost to treatment · people with both severe mental illness and substance misuse

1 finding from 1 review

Psychosocial interventions for people with both severe mental illness and substance misuse 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Very low

INTERMITTENT (EARLY‐BASED) vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

INTERMITTENT (EARLY‐BASED) may leads to higher leaving the study early/loss to compared with MAINTENANCE THERAPY (low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.67 [1.17, 2.37]
5 studies · 562 participants
Low

INTERMITTENT (CRISIS INTERVENTION) vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether INTERMITTENT (CRISIS INTERVENTION) changes leaving the study early/ loss to compared with MAINTENANCE THERAPY (very low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.57 [1.23, 2]
1 study · 237 participants
Very low

INTERMITTENT (GRADUALLY INCREASED DRUG‐FREE PERIODS) vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether INTERMITTENT (GRADUALLY INCREASED DRUG‐FREE PERIODS) changes leaving the study early/ loss to compared with MAINTENANCE THERAPY (very low certainty).

1 finding from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 2.12 [0.7, 6.37]
3 studies · 257 participants
Very low

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Leaving the study early/ loss to · patients with schizophrenia

It is very uncertain whether INTERMITTENT (DRUG HOLIDAY) changes leaving the study early/ loss to compared with MAINTENANCE THERAPY (very low certainty).

2 findings from 1 review

Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.01 [0.46, 2.2]
2 studies · 62 participants
Very low
Intermittent drug techniques for schizophrenia 2013 · Cochrane Headline outcomes only
RR 1.63 [1.23, 2.15]
10 studies · 996 participants
Low