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Evidence found and GRADE certainty

6 questions · 6 findings · 3 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 1 · 16.7%Moderate 2 · 33.3%High 0 · 0%

Corticosteroids vs placebo or no treatment

Intraventricular haemorrhage · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes intraventricular haemorrhage compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone acetate plus phosphate vs betamethasone phosphate – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether betamethasone acetate plus phosphate changes intraventricular haemorrhage compared with betamethasone phosphate – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone 12‐hourly vs 24‐hourly dosing – fetal/neonatal outcomes

Intraventricular haemorrhage · women at risk of preterm birth

It is very uncertain whether betamethasone 12‐hourly changes intraventricular haemorrhage compared with 24‐hourly dosing – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Intraventricular haemorrhage, Papile grade 3/4 · the fetus/neonate/infant

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A9: Severe intraventricular haemorrhage (grade 3 or 4) – all fetuses… compared with single course (moderate certainty).

1 finding from 1 review