Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 2 · 28.6%Low 2 · 28.6%Moderate 2 · 28.6%High 0 · 0%

nHFV vs NCPAP

Intraventricular haemorrhage, Papile grade 3/4 · newborn (term* and preterm) infants with respiratory distress for initial respiratory support

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nCPAP used (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 1.17 [0.36, 3.78]
4 studies · 531 participants
Low

nHFV vs NIPPV or NIV

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

nHFV vs HFNC

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

nHFV vs NCPAP

Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with planned extubation

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nCPAP (moderate certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.8 [0.57, 1.13]
3 studies · 1117 participants
Moderate

nHFV vs NIPPV or NIV

Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with planned extubation

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nIPPV (moderate certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.78 [0.55, 1.1]
4 studies · 1162 participants
Moderate

nHFV vs nIPPV following failure of initial non‐invasive respiratory support

Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with failure of initial non‐invasive respiratory support

nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
RR 0.47 [0.02, 10.87]
1 study · 39 participants
Low

nHFV vs invasive respiratory therapy

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress for initial respiratory support

1 finding from 1 review

Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress 2024 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported