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What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 2 reviews · Headline outcomes only

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No studies found 2 · 22.2%GRADE not reported 0 · 0%Very low 5 · 55.6%Low 2 · 22.2%Moderate 0 · 0%High 0 · 0%

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… showed no clear difference in incidence of serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical small molecule inhibitors (ruxolitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Topical small molecule inhibitors… changes incidence of serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Perineural dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block
1 finding from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review