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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews · Oral and maxillofacial surgery

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No studies found 0 · 0%GRADE not reported 2 · 33.3%Very low 3 · 50%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure

MRONJ (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)
1 finding from 1 review
  • Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
    90 days
    All participants had complete mucosal coverage without any signs of MRONJ at the final control examination 90 days postoperatively (77 randomised; 1 RCT); no case of postoperative MRONJ in either group; effect not…
    1 study · 77 participants
    GRADE not reported

Delicate surgery and wound closure by primary intention vs Non-traumatic tooth avulsion and wound closure by secondary intention

MRONJ (incidence proportion) · People treated with oral bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence proportion) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence proportion) compared with standard care (very low certainty).

1 finding from 1 review

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)

It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review

Subperiosteal prepared (SPP) wound closure after tooth extraction vs Epiperiosteal prepared (EPP) wound closure after tooth extraction

MRONJ after tooth extraction (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)

Subperiosteal prepared (SPP) wound closure after tooth extraction showed no clear difference in MRONJ after tooth extraction (incidence proportion) compared with epiperiosteal prepared (EPP) wound closure after tooth extraction (low certainty).

1 finding from 1 review