What do systematic reviews say?

Hand mallet (osteotomes) vs Electric mallet

Hand mallet (osteotomes) showed no clear difference in implant failure compared with electric mallet; GRADE not reported.

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  before loading
  OR 1.00 [0.06, 16.56]
  1 study · 80 participants
  GRADE not reported

Implant surface smoothening added to systemic antibiotics + resective surgery + local antibiotics vs No implant surface smoothening (same surgical protocol)

Implant surface smoothening added to systemic antibiotics +… showed no clear difference in implant failure compared with no implant surface smoothening (same surgical protocol); GRADE not reported.

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  2 years
  RR 0.3 [0.01, 6.47]
  1 study · 17 participants
  GRADE not reported

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  6 months
  No implant failures occurred in any of the groups (both trials).
  2 studies · 40 participants
  GRADE not reported

Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  6 months
  No implant failure occurred in any of the groups.
  1 study · 22 participants
  GRADE not reported

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  6 months
  After 6 months there were no drop-outs, implant failures or complications.
  1 study · 42 participants
  GRADE not reported

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  4 months (18 weeks)
  No implant failures occurred in any of the groups.
  1 study · 28 participants
  GRADE not reported

Metronidazole gel 25% (local antibiotic) vs Ultrasonic debridement

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  12 weeks
  No implant failures occurred in any of the groups.
  1 study · 27 participants
  GRADE not reported

Air-abrasive / Vector system debridement vs Manual debridement (carbon fibre curettes)

• Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes

  6 months
  No implant failures occurred in any of the groups.
  1 study · 11 participants
  GRADE not reported

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in implant failure compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

• Interventions for replacing missing teeth: dental implants in fresh extraction sockets (immediate, immediate‐delayed… 2010 · Cochrane All outcomes

  1 year
  RR 4.33 [0.76, 24.56]
  2 studies · 110 participants
  GRADE not reported

ARP with allograft plus synthetic cell-binding peptide P-15 vs ARP with allograft without P-15

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes

  6 months
  Outcome not reported
  0 studies
  No studies found

ARP with allograft (bone graft) vs ARP with xenograft

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes

  6 months
  Outcome not reported
  0 studies
  No studies found

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

The review found no eligible studies for this question.

• Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes

  9 months
  Outcome not reported
  0 studies
  No studies found

ARP with alloplast vs ARP with xenograft

It is very uncertain whether ARP with alloplast changes implant failure rate compared with ARP with xenograft (very low certainty).

• Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes

  6 to 8 months
  Not estimable; 1 trial (Patel 2013) reported that none of the implants failed after 12 months of loading
  1 study · 25 participants
  Very low

Two-stage sinus lift + buccal onlay iliac grafts WITH platelet-rich plasma (PRP) vs Same grafts WITHOUT PRP (split-mouth)

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  2 years post-loading
  No statistically significant difference for any outcome; data not shown (Raghoebar 2005)
  1 study · 5 participants
  GRADE not reported

Buccal onlay iliac grafts fixed with titanium screws vs Buccal onlay iliac grafts fixed with resorbable screws (split-mouth)

• Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant… 2009 · Cochrane All outcomes

  2 years post-loading
  No statistically significant difference for any outcome; data not shown (Raghoebar 2006)
  1 study · 8 participants
  GRADE not reported